Lipopolysaccharide Differentially Alters Oligodendrocyte Precursor Cell Proliferation
نویسندگان
چکیده
منابع مشابه
Diazoxide Promotes Oligodendrocyte Precursor Cell Proliferation and Myelination
BACKGROUND Several clinical conditions are associated with white matter injury, including periventricular white matter injury (PWMI), which is a form of brain injury sustained by preterm infants. It has been suggested that white matter injury in this condition is due to altered oligodendrocyte (OL) development or death, resulting in OL loss and hypomyelination. At present drugs are not availabl...
متن کاملHypoxia Alters Cell Cycle Regulatory Protein Expression and Induces Premature Maturation of Oligodendrocyte Precursor Cells
BACKGROUND Periventricular white matter injury (PWMI) is a common form of brain injury sustained by preterm infants. A major factor that predisposes to PWMI is hypoxia. Because oligodendrocytes (OLs) are responsible for myelination of axons, abnormal OL development or function may affect brain myelination. At present our understanding of the influences of hypoxia on OL development is limited. T...
متن کاملPrecursor Cell Transitions in Oligodendrocyte Development
Address correspondence to Mark Noble, Huntsman Cancer Institute, Rm. 4280, Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112. Tel.: (801) 585-7167. Fax: (801) 585-7120. E-mail: [email protected] The physiological demands made upon precursor cell populations during different developmental epochs can be remarkably divergent, particularly in tissues that do not...
متن کاملCaffeoylquinic Acid Enhances Proliferation of Oligodendrocyte Precursor Cells
This report evaluates the protective effect of caffeoylquinic acid (CA) injury to oligodendrocyte precursor cells (OPCs) by promoting the formation of oligodendrocytes. Neonatal rat brain was used to isolate primary OPCs and non-lethal CoCl2 was used to induce hypoxic stress to inhibit the differentiation of OPCs. Differentiation of OPCs was estimated by survival assay and the expressions of my...
متن کاملAspirin Promotes Oligodendrocyte Precursor Cell Proliferation and Differentiation after White Matter Lesion
Cerebral white matter lesion (WML) is one of the main causes for cognitive impairment and is often caused by chronic cerebral hypoperfusion. A line of evidence has shown that aspirin has neuroprotective effects and produces some benefits in long-term outcome and survival for ischemic stroke patients. However, whether aspirin exerts a protective effect against WML is still largely unknown. Here,...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2019
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2019.33.1_supplement.451.4